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PROTEASOME ENDOPEPTIDASE COMPLEX
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DeCS
Descriptor
English
:
Proteasome Endopeptidase Complex
Descriptor
Spanish
:
Complejo de la Endopetidasa Proteasomal
Descriptor
Portuguese
:
Complexo Endopeptidase Proteassoma
Tree Number:
D05.500.562.500
D08.811.277.656.918
D08.811.600.730
Definition
English
:
A large multisubunit complex that plays an important
role
in the degradation of most of the cytosolic and
nuclear proteins
in
eukaryotic cells
. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated
proteins
and protein activated via
ornithine decarboxylase
antizyme.
See Related
English
:
Ubiquitin-Protein Ligase Complexes
History Note
English
:
2005; use PROTEASOME ENDOPEPTIDASE COMPLEX (NM) 1986-2004
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
38685
Unique Identifier:
D046988
Occurrence in VHL
:
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